منابع مشابه
Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.
MicroRNAs (miRNA) can act as oncogenes or tumor suppressors and modulate the expression of approximately one third of all human genes. To test the hypothesis that adverse alleles in miRNA-related genes may increase the risk for esophageal cancer, we assessed the associations between esophageal cancer risk and 41 potentially functional single nucleotide polymorphisms (SNP) in 26 miRNA-related ge...
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Recent evidence suggests that genetic variations in the insulin-like growth factor (IGF)-IGF receptor (IGFR)-IGF binding proteins (IGFBP) axis may impact an individual's susceptibility to lung and esophageal cancer, but individually published results are inconclusive. Our meta-analysis aimed at providing a more precise estimation of these associations. An extensive literature search was conduct...
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As one of the most aggressive cancers, esophageal squamous cell carcinoma (ESCC) is the sixth leading cause of cancer deaths worldwide and particularly common in Asia. Over the decades, the clinical management of ESCC patients has barely advanced; and the overall survival remains poor, largely because its molecular basis, especially the genomic abnormalities, is obscure, and no targeted therapy...
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Background: Gastric cancer (GC) has an apparent hereditary component. However, in a large fraction of gastric cases, no known genetic syndrome or family history can be identified, suggesting the presence of ‘missing heritability’ in GC etiology. Genome-wide association studies (GWAS) and traditional candidate gene studies have both led to the identification of multiple replicable common genetic...
متن کاملCancer Prevention Research Genetic Variations in MicroRNA-Related Genes Are Novel Susceptibility Loci for Esophageal Cancer Risk
MicroRNAs (miRNA) can act as oncogenes or tumor suppressors and modulate the expression of approximately one third of all human genes. To test the hypothesis that adverse alleles in miRNA-related genes may increase the risk for esophageal cancer, we assessed the associations between esophageal cancer risk and 41 potentially functional single nucleotide polymorphisms (SNP) in 26 miRNA-related ge...
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ژورنال
عنوان ژورنال: Gastrointestinal Tumors
سال: 2015
ISSN: 2296-3774,2296-3766
DOI: 10.1159/000434637